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Digital Therapeutics: Software-Powered Medicine

Digital Therapies

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Digital Therapeutics: Software-Powered Medicine

By 2025, the market for digital therapeutics is expected to reach $7.8 billion

The Promise of Software-Powered Medicine

What Are Digital Therapeutics (DTx)?

  • LTherapeutic interventions driven by technology and software programs
  • Used to alleviate symptoms of physiological and neurobehavioral conditions
  • Therapies improve outcomes when combined with standard treatments

The Benefits Of DTx

  • Digital Treatment
  • Offers new options for otherwise unmet needs
  • May help reduce reliance on medication

Wide-Ranging Applications

  • Diabetes
  • Obesity

Diseased systems, including

  • Respiratory
  • Cardiovascular
  • Central nervous
  • Gastrointestinal

What can DTx do?
Combining surgical tools and digital software surgeons can not relieve tremors without invasive surgeries

Tech-Powered Tremor Relief

Exablate Neuro has been used in over 50 medical centers around the world to treat over 2,000 patients
May relieve the symptoms of

  • Essential Tremors: Involuntary trembling of extremities and speech
  • Parkinson’s Disease: Uncontrollable bodily movements

How It Works
Treatment combines the use of MRI imaging, high-intensity ultrasound, and a specialized cooling helmet

High-intensity ultrasound

  • Sees through skin to the bone
  • Targets the Vim point to reduce the tremor

Magnetic resonance imaging (MRI)

  • Guide the procedure and prevents damage of healthy tissue
  • Monitor the patient’s temperature in the area

Cooling helmet

  • Controls the patient’s skull temperature
  • Prevents overheating from ultrasonic heat production

The Benefits

  • Non-invasive & minimal risk
  • Lower risk of infection
  • Shorter recovery time
  • No collateral tissue damage

Potential side effects

  • Tingling in fingers and tongue
  • Difficulty with sense of balance
  • Usually temporary and relatively minor

Specialized video games help patients practice essential skills, from attention and memory to relaxation, all while having fun

Video Games As Medicine?

Video games may help builds key skills, including

  • Working Memory: Short term ability to recall information — such as a to-do list
  • Executive Functioning: Ability to manage emotions, attention, and planning
  • Selective Attention: Processing, filtering and responding to competing stimuli

Akili Interactive’s Selective Stimulus Management Engine (SSME™)
How It Works

  • Gameplay is specially designed to utilize key skills
  • Adaptive algorithms adjust to each player’s skill level

Sensory and motor stimuli are deployed to:

  • Target and activate key areas of the brain
  • Build new neurological links through regular practice

May help alleviate symptoms of

  • ADHD
  • Autism
  • Multiple sclerosis
  • Major depression

More On The Way
New gaming engines are currently in development

  • Spatial Navigation Engine (SNAV™)
  • Affective Engine (AAFF™)

These new engines are designed to help patients with

  • Traumatic brain injuries
  • ICU delirium
  • Lupus

Gaming With Biofeedback

How It Works
Biofeedback is used to indicate the patient’s anxiety or attention level

  • Heart rate monitor: Tracks pulse rate and volume
  • Respirometer: Tracks breathing and exhalations
  • Temperature: Tracks peripheral blood flow
  • Skin Conductance Level: Monitors for sweat gland activity
  • Galvanic Skin Response: Monitors for muscle tension
  • Eye Tracking: Monitors attention to task

Gameplay adapts to the player’s state of mind and requires mindful response to continue

  • Mighteor: Play becomes more difficult as anxiety increases, requiring the player to independently relax in order to continue
  • Quotient: Slows gameplay as attention wanders, requiring the player to practice selective focus in order to continue

May help alleviate symptoms of

  • Anxiety
  • ADHD
  • Autism

Cutting-Edge Therapies: New & Coming Soon

In 2018, Pear Therapeutics launched the first digital rehabilitation platforms to gain FDA approval

  • reSET for Substance Use Disorder
  • reSET-O for Opioid Use Disorder (OUD)

Both programs provide digital cognitive behavioral therapy to complement outpatient treatment

In 2019, Israeli startup VRHealth began testing virtual reality for pain management

  • Immersive VR experiences distract patients from the pain
  • Combined with physical therapy to address underlying issues
  • Emerging research shows promising uses for digital diagnosis and treatment
  • Eye Tracking: May help streamline diagnosis Autism and symptoms levels
  • Voice Markers: May help track Alzheimer’s, depression, schizophrenia, and Parkinson’s disease
  • Neurologic Music Therapy: May improve motor, speech, and cognitive function after disease or injury

Are digital therapies the next frontier in medicine?

Digital Theraputics

Sources:
https://www.medicaldevice-network.com/features/virtual-reality-pain-relief-2019/
https://www.ncbi.nlm.nih.gov/pubmed/30392627
https://medcitynews.com/2020/01/pear-therapeutics-unveils-several-new-licensing-deals/
https://dtxalliance.org/dtx-solutions/
https://www.globenewswire.com/news-release/2019/10/30/1938035/0/en/Digital-Therapeutics-Market-Worth-7-83-Billion-By-2025.html
https://dtxalliance.org/wp-content/uploads/2018/09/DTA-Report_DTx-Industry-Foundations.pdf
https://www.timesofisrael.com/israeli-startup-uses-ultrasound-waves-to-reduce-parkinsons-tremors/
https://peartherapeutics.com/products/reset-reset-o/
https://www.akiliinteractive.com/programs-products
https://www.akiliinteractive.com/science-and-technology
https://www.psychiatrictimes.com/anxiety/biofeedback-and-anxiety
https://www.scientificamerican.com/article/working-memory-how-you-keep-things-ldquo-in-mind-rdquo-over-the-short-term/
http://www.ldonline.org/article/29122/
https://www.additudemag.com/video-games-biofeedback-adhd-anxiety-emotional-control/
https://www.mobihealthnews.com/content/neuropluss-eeg-controlled-video-game-helps-kids-manage-their-adhd-study-shows

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